Where in the World is Karen Walker? is the 2nd episode of the tenth season and 212th overall which was aired from NBC on October 11, 2018.
Karen disappears after seeking help from her friends, but with Grace distracted with her campaign, Will starting a new career teaching law, and Jack avoiding marriage, none of them realize why she's left until Malcolm reveals that he told Stan of their affair. Karen is then served divorce papers.
- Eric McCormack (Will Truman)
- Debra Messing (Grace Adler)
- Megan Mullally (Karen Walker)
- Sean Hayes (Jack McFarland)
- Alec Baldwin (Malcolm Widmark)
- Brian Jordan Alvarez (Estefan)
- Charles C. Stevenson Jr. (Smitty)
- Joy Osmanski (Trish Yashida)
- David Douglas (Edward)
- Connie Shin (Student)
- Jake Green (Tour Announcer)
- Jennifer Kenyon (Linda)